Use an Enzadent Dual-Ended Toothbrush or Fingerbrush to apply daily or as directed by your veterinarian. Dual-Ended Bristles Specially Designed to Help Remove Plaque and Food Debris. Toothbrushing is an important step in maintaining the oral health of your pet. For best results, brush 3-4 times per week using Enzadent Enzymatic Toothpaste. Your veterinarian may give you specific directions. Follow his or her advice closely.