S-Adenosyl-225 (SAMe) Formulated to improve liver metabolic activity and restore proper liver function. Its unique, enteric-coated delivery system allows it to stand up formidably to stomach acid and effectively deliver the S-Adenosylmethionine 1,4 butanedisulfonate (SAMe) to the small intestine for proper absorption. Both strengths contain SAMe and other important ingredients for proper liver support such as milk thistle to help protect liver cells from toxins and reduce damage to those cells caused by some prescription drug use. It also contains antioxidants to help neutralize oxygen free radicals, amino acids to stimulate glutathione synthesis and reduce oxidative damage, B-vitamins to provide nutritional support ensuring proper protein and energy metabolism, and vitamin B-6 for synthesis of cysteine in the liver detoxification pathway.