Each Curaflex 2 bonelet contains: 500 mg Glucosamine Hydrochloride HCl-Glucosamine is a natural compound found in the body tht has been shown to stimulate the body's ability to maintain healthy joints. 500 mg Methysulfonylmethane (MSM)-MSM is a source of organic sulfur, a nutrient found in your pet's body. Sulfer is a compound that is used by cartilage. DAILY ADDMINISTRATION AS A SUPPLEMENT FOR DOGS: Recommended Inital Administration (4-6 weeks). under 15 lbs 1/2 chewable Bonelet. 16-30 lbs 1 chewable Bonelet. 31-60 lbs 2 chewable Bonelets. 61-100 lbs 3 chewable Bonelets.